Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface-Reference-Cited by-同舟云学术

Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface

Published:2023-01-18 Issue:1 Volume:508 Page:12-16
ISSN:1607-6729
Container-title:Doklady Biochemistry and Biophysics
language:en
Short-container-title:Dokl Biochem Biophys

Author:

Ivanova O. K.,Sharapova T. N.,Romanova E. A.,Yashin D. V.,Sashchenko L. P.

Abstract

Abstract To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25, and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. The appearance of these proteins on the surface of this subpopulation of lymphocytes allows them to induce programmed cell death in HLA-negative tumor cells.

Publisher

Pleiades Publishing Ltd

Subject

General Chemistry,Biochemistry,General Medicine,Biophysics

Link

https://link.springer.com/content/pdf/10.1134/S160767292270003X.pdf

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