Complexation studies with 90Y from a novel 90Sr-90Y generator

Abstract

Some features of a novel 90Sr-90Y generator which employs supported liquid membrane (SLM) to separate carrier-free 90Y from 90Sr present in the high level waste of the spent fuel of reactor are described. After ascertaining the purity of 90Y particularly with respect to 90Sr breakthrough, its complexation was studied with a few oxo/aza donor ligands, such as DTPA, EDTMP, DOTA, TETA and a cyclic phosphonate, CTMP. These studies were primarily carried out to adjudge the quality of the 90Y obtained from a novel 90Sr-90Y generator and ascertain its usability for labelling biomolecules such as antibodies and peptides. The DOTA complexes are most stable at 37 C in human serum; they appear to be ideal bifunctional chelating agent for use in radioimmunotherapy with 90Y.