Lead (Pb) column for concentration of 99mTc-pertechnetate

Abstract

Because of the high content of inactive molybdenum in neutron irradiated MoO3, large columns containing alumina or gel are needed to produce chromatographic 99Mo→99mTc generator. This results in large elution volumes containing relatively high 99Mo breakthrough and low concentrations of 99mTcO4 -. The decrease in specific volume of 99mTc places a limitation on reconstitution of some kits for 99mTc radiopharmaceuticals applied in diagnostic nuclear medicine. Hence concentration technique is mandatory for effective utilization of (n,γ) produced 99Mo/99mTc generators at the start of its life whereas in case of fission 99Mo/99mTc generator the technique may be quite useful at the end of first week of its life. We report post elution concentration of 99mTc using in house prepared Pb column. The high bolus volumes (10–60 ml saline) can conveniently be concentrated in ∼1 ml of saline.