Synthesis and crystallographic structure of boron derivatives of N-(2-hydroxy-naphthylmethyl)-L-proline

Abstract

Abstract A highly diastereoselective synthesis (>98%) of novel chiral (3aS)-4-oxo-6-phenyl-2,3,3a,4,6,14-hexahydro-1H-naphtho[1,2-e]pyrrolo[1′,2′:3,4][1,3,2]oxazaborolo-[2,3-b][1,3,2]oxazaborinin-15-ium-6-uide (2a) and (3aS)-6-(naphthalen-2-yl)-4-oxo-2,3,3a,4,6,14-hexahydro-1H-naphtho[1,2-e]pyrrolo[1′,2′:3,4][1,3,2]oxazaborolo[2,3-b][1,3,2] oxazaborinin-15-ium-6-uide (2b) compounds is described and details of the crystal structures are presented.