Management of Aromatase Inhibitor–Induced Arthralgia

Abstract

Aromatase inhibitors (AIS) are commonly used as adjuvant treatment in postmenopausal women with hormone receptor–positive early breast cancer. With both steroidal and nonsteroidal AIS, AI-induced arthralgia is frequently observed. The mechanism of AI-induced arthralgia remains unknown, and the data available from clinical trails using AIS are limited. We review the pertinent information from a clinical perspective, including an algorithm to treat AI-induced arthralgia.