Pharmacokinetic and Dynamic of Furosemide in Peritoneal Dialysis Patients

Author:

Lamarche Caroline1,Pichette Maude1,Ouimet Denis1,Vallée Michel1,Bell Robert1,Ouellet Georges1,Stewart John2,Pichette Vincent13

Affiliation:

1. Department of nephrology Maisonneuve-Rosemont Hospital, Montreal, Canada

2. Sanofi Canada Laval, Quebec Montreal, Canada

3. Maisonneuve-Rosemont Hospital Research Center Montreal, Canada

Abstract

The aim of our study was to evaluate the efficacy and bioavailibility of a commonly used oral furosemide dose (500 mg) compared to a 250 mg intravenous (IV) dose in PD patients with significant residual renal function (urine volume > 100 mL). We also evaluated the immediate blood pressure effect in these patients. The data were obtained from a study we performed for the homologation of a 500-mg dose of furosemide by Health Canada.

Publisher

SAGE Publications

Subject

Nephrology,General Medicine

Reference6 articles.

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Clinical Use of Diuretics;Pediatric Nephrology;2022

2. Clinical Use of Diuretics;Pediatric Nephrology;2021

3. Pharmacodynamics of 250 mg and 500 mg oral furosemide in peritoneal dialysis;Int. Journal of Clinical Pharmacology and Therapeutics;2019-12-01

4. The usefulness of thiazide and thiazide-like diuretics in advanced chronic kidney disease;Int. Journal of Clinical Pharmacology and Therapeutics;2019-11-01

5. Population pharmacokinetic modeling of furosemide in patients with hypertension and fluid overload conditions;Pharmacological Reports;2017-06

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