THE RESULTS OF USING A BIOACTIVE GLASS-BASED COATING BY DEPOSITION ON THE CONTACT SURFACE OF PLATES IN BONE FRACTURES ASSOCIATED WITH TUMORS

Abstract

The article reports on the results of surgical treatment in 20 patients with bone tumors using a coating containing bioactive glass on the contact surface of the fixation plate. As a result of metallic osteosynthesis of the bones, infectious complications were observed in 1 (5%) patient and tumor recurrence was observed in 2 (10%) patients. Limb function after metallic osteosynthesis ranged from 72.3% to 97.4% depending on the location of the lesion focus. The quality of life of the operated patients increased to 75–85 points. Thus, the use of plates with bioactive glassbased material deposited on the contact surface of the plate, in metallic osteosynthesis for pathological bone fracture or at the risk of pathological bone fracture achieves more effective integration of metal plate with bone. Consequently, a better functional stability of the bone is achieved at the fracture site. Morphological examination of bone biopsy samples from the implantation site of the plate and the plate itself with the deposited bioactive glass-based coating revealed active regeneration of bone tissue. This resulted in an increase in the density of the restored bone. According to the results of histological and morphometric examination it can be stated that deposition of a material containing bioactive glass on the contact surface of the metal plate promotes reparative osteogenesis at the site of bone damage and its morphogenesis of the lamellar type.