PLASMA LEVELS OFSERUM METALLOPROTEINASES MMP-9, MMP-2 AND TISSUEINHIBITORSTIMP-2 IN NEWBORNS WITH NECROTIZING ENTEROCOLITIS
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Published:2021-03-27
Issue:1
Volume:11
Page:79-81
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ISSN:2199-885X
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Container-title:Archiv Euromedica
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language:
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Short-container-title:AREM
Author:
Khvorostov IgorORCID,
Smirnov Ivan Evg.ORCID
Abstract
The analysis of the balance of elastase (MMP-2, MMP-9) and TIMP-4 was performed in order to determine its involvement in the pathogenesis of NEC. A progressive duration of NEC with sepsis is accompanied by increased serum concentrations of MMP-9, MMP-2 and TIMP-4. Increases in concentrations of MMP-2>503 ng/ml, MMP-9>812 ng/ml TIMP-4>1404 ng/ml can be regarded as statistically significant predictors of fatal outcome of NEC. The proposed method for determination of the outcomes of NEC in newborns is characterized by high sensitivity (94%) and specificity (87%).
Publisher
European Scientific Society