A COMBINATION TREATMENTFOR CHRONIC PERIODONTITIS ASSOCIATED WITH DYSBIOSIS OF ORAL MICROBIOTA AND ASSESSMENT OF ITS EFFECT

Abstract

The high virulence of periodontal pathogenic bacteria, progression of chronic periodontitis in patients with comorbidities not always treated efficiently with conventional therapies, may result in oral dysbiosis. In this connection, the development of new pathogenetically oriented treatment methods and their improvement is of both theoretical and practical interest to the dental community. Aim: to improve the algorithms for the treatment of periodontitis associated with comorbidities and to assess its effectiveness using an immobilized synbiotic developed by the authors. Methods: clinical, microbiological, analytical, and statistical methods were used in our study. The study included clinical examination and treatment of 93 patients of both genders (37 female and 56 male patients) between 18 and 65 years old with moderate generalized chronic periodontitis. The results confirm the effectiveness of adding the proposed symbiotic to the treatment of chronic periodontitis with underlying gastrointestinal, endocrine and cardiovascular diseases in oral administration to restore the gut microbiota as well as applied locally in the periodontal pocket.