To the question of connective tissue disorders in children and adolescents with orthopedic pathology

Abstract

Clinical and histological changes were studied in 96 adolescents with knee pathology of non-traumatic genesis, with signs of connective tissue disease (CTD). The detection of connective tissue dysplasia was carried out according to the data of a clinical examination, functional and radiation diagnostic methods in accordance with the Russian recommendations for algorithms for the diagnosis and treatment of children with connective tissue disease (2015). Serial sections stained with hematoxylin and eosin were examined on an Olympus CX-41 microscope at a magnification of ×100, ×200, ×400. Some of the preparations were additionally stained with picrofuchsin according to van Gieson. Signs of a pronounced diffuse pathological process of a degenerative-dystrophic nature were revealed, caused by hypoxic and metabolic disorders, which led to the development of pain syndrome and became a reason for subsequent surgical intervention.