Red bone marrow damage in COVID-19 pathogenesis caused by SARS-CоV-2

Abstract

With the emerging of new strains of the SARS-CoV-2 coronavirus (such as B.1.1.529 for example), despite numerous studies to create effective vaccines, it becomes obvious that the relevance of studying the pathomorphology of tissue structures with damaged cellular targets has increased manifold. Most knowledge on genes of pathogenicity loses its importance for the development of antiviral agents since the reservoir for the virus is the cells, in which SARS-CoV-2 then persists. These data are more important for the development of vaccines, and the treatment strategy should be based on damaged cellular targets. The mechanisms of hypoxia in patients infected by SARS-CoV-2 with COVID-19 do not have an exhaustive explanation based only on the acute alveolar damage. Our investigation deals with the data on pathologic red bone marrow in patients with a fatal COVID-19 outcome against the background of various indicators of erythrocytes in clinical blood tests. We found in the structure of the red bone marrow that there is damage to the stroma and parenchyma as well as pathomorphological signs of damage to erythropoiesis in the patients of both groups. The data obtained on the cellular targets of SARS-CoV-2 can serve as a fundamental platform for the development of targeted conservative therapy in the treatment of patients infected with SARS-CoV-2, and should also be taken into account in severe COVID-19 cases with the risk of unfavorable prognosis.