THE RELATIONSHIP BETWEEN THE ACTIVITY OF SEX HORMONE RECEPTORS AND PROLIFERATIVE ACTIVITY OF KERATINOCYTES IN POSTMENOPAUSE

Abstract

Using the method of immune histochemistry, the qualitative and quantitative features of gender hormone receptors in the structure of the mucous membrane epithelium of woman cervix in the postmenopausal period were studied and its relationship with the proliferative activity of keratinocytes was explored. The significance of estrogen deficiency in proliferative activity in the epithelial structure of the mucous membrane of the cervix in the postmenopausal period is shown. Additional targets for therapeutic action have been identified in order to regulate and normalize proliferative activity and prevent neoplasia and malignancy in the structure of the cervical epithelium. It has been established that the most variable indicators are in the structure of the mucous membrane of the exocervix, and the most stable - in the endocervix. A promising direction in predicting disruptions of intercellular interactions leading to malignancy in the structures of the mucous membrane of the cervix in postmenopausal women is the standardization of Ki-67 assessment against the background of indicators of the level of estrogen and progesterone reception in the system of differons of the epithelial layer.