Rare clinical observation of pronounced response to immunotherapy in a patient with anaplastic thyroid cancer-Reference-Cited by-同舟云学术

Rare clinical observation of pronounced response to immunotherapy in a patient with anaplastic thyroid cancer

Published:2024-06-28 Issue:1 Volume:14 Page:63-69
ISSN:2411-4634
Container-title:Head and Neck Tumors (HNT)
language:
Short-container-title:Opuholi golovy i šei

Author:

Vontlaya D. M.¹,Stryapikhina O. V.²,Egorin A. A.¹^ORCID,Logvinenko A. V.¹,Tamrazov R. I.¹^ORCID

Affiliation:

1. Multidisciplinary clinical medical center “Medical city”

2. Tyumen State Medical University, Ministry of Health of Russia

Abstract

Anaplastic thyroid cancer is the rarest and the most aggressive form of thyroid cancer. It comprises 1-2 % of all cases and is characterized by rapid growth. median survival of patients with this pathology is about 5 months. Clinical manifestations of the disease are rapid deformation in the neck area, progressive respiratory distress, and dysphagia.The article describes a clinical case of a response of unresectable, BRAF-negative, PD-L1-positive (programmed death-ligand 1) anaplastic thyroid cancer to immunotherapy with pembrolizumab.

Publisher

Publishing House ABV Press

Reference14 articles.

1. Luk'yanov S.A., Sergiyko S.V., Titov S.E. et al. New opportunities for preoperative diagnosis of anaplastic thyroid cancer. Opukholi golovy i shei = Head and Neck Tumors 2021;11(1):34-40. (In Russ.). DOI: 10.17650/2222-1468-2021-11-1-34-40

2. Pylev A.L., Zhandarova A.A., Petrov K.S. et al. Anaplastic thyroid cancer. Is there a light at the end of the tunnel? Opukholi golovy i shei = Head and Neck Tumors 2020;10(1):10-9. (In Russ.). DOI: 10.17650/2222-1468-2020-10-1-10-19

3. Nikiforovich P.A., Rumyantsev P.O., Sleptsov I.V. et al. Treatment of BRAFV600E-positive anaplastic thyroid carcinoma: case report. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology журнал 2020;19(5):131-44. (In Russ.). DOI: 10.21294/1814-4861-2020-19-5-131-144

4. Mudunov A.M., Pheshkhova B.G., Zeynalova P.A. et al. The difficulties of diagnosis and features of the clinical course of anaplastic thyroid cancer. A clinical case. MD-Onco 2022;2(4):22-6. (In Russ.). DOI: 10.17650/2782-3202-2022-2-4-22-26

5. Samsonov R., Burdakov V., Shtam T. et al. Plasma exosomal miR-21 and miR-181a differentiates follicular from papillary thyroid cancer. Tumour Biol 2016;37(9):12011-21. DOI: 10.1007/s13277-016-5065-3