Affiliation:
1. Orenburg Regional Clinical Oncological Dispensary; Orenburg State Medical University
Abstract
Osteopontin is an extracellular matrix protein which is produced by different types of cells and plays an important functional role in many biological processes. This review discusses the main functions of osteopontin, its role in the progression and chemoresistance of malignant neoplasms, in the regulation of epithelial-mesenchymal transition, angiogenesis, and the body’s immune response to the tumor. The article considers the currently known mechanisms by which osteopontin affects to the survival, mobility and invasion of tumor cells, to tumor sensitivity to drug treatment, as well as the prospects for a integrated study of the predictive significance of osteopontin, markers of hypoxia, angiogenesis, epithelial- mesenchymal transition, and immunological tolerance.
Publisher
Publishing House ABV Press
Subject
Cancer Research,Biochemistry, medical,Genetics(clinical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Reference68 articles.
1. Denhardt D.T., Guo X. Osteopontin: a protein with diverse functions. FASEB J 1993;7(15):1475–82.
2. Berezin A.E., Panasenko T.A., Koretskaya E.Yu. Osteopontin as a new biological marker of cardiovascular remodeling. Ukrainskij kardiologicheskij zhurnal = Ukrainian Journal of Cardiology 2010;4:98–102.(In Russ.).
3. Shibanova I.A., Khryachkova O.N. The use of biomarkers of phosphoruscalcium metabolism for the diagnosis and risk stratification of patients with coronary heart disease. Russkij medicinskij zhurnal = Russian Medical Journal 2017;20:1409–14.(In Russ.).
4. Wai P.Y., Kuo P.C. The role of osteopontin in tumor metastasis. J Surg Res 2004;121(2):228–41. DOI: 10.1016/j.jss.2004.03.028.
5. Gimba E., Brum M., Moraes G.N. Fulllength osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review). Int J Oncol 2019 Feb;54(2):420–30. DOI: 10.3892/ijo.2018.4656.
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