Role of TRIM16 in cancers development-Reference-Cited by-同舟云学术

Role of TRIM16 in cancers development

Published:2019-01-04 Issue:4 Volume:5 Page:72-77
ISSN:2413-3787
Container-title:Advances in molecular oncology
language:
Short-container-title:Usp. mol. onkol

Author:

Spirina L. V.¹^ORCID,Kondakova I. V.²^ORCID,Tarasenko N. V.³^ORCID

Affiliation:

1. Саncеr Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University

2. Саncеr Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

3. Siberian State Medical University; Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences

Abstract

Тhe protein TRIM16 is involved in key intracellular processes, such as proliferation, cell differentiation and programmed death, including intrinsic and extrinsic apoptosis, autophagy-dependent cell death and immunogenic cell death. The TRIM16 protein acts the proteins TPD43, Gli-1, RARβ, Snail components and MAPK signaling pathway, cadherins, caspases and is also associated with the regulation of the immune system via direct and indirect mechanisms. The influence of TRIM16 protein on the pathogenesis of hormone-dependent tumors is well-known. Further study of the TRIM16 role in the development and progression of malignant neoplasms will form the basis for the development of new methods for predicting the course of the malignant process.

Publisher

Publishing House ABV Press

Subject

Cancer Research,Biochemistry (medical),Genetics (clinical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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