Affiliation:
1. Scientific and Educational Professional Center of Genetic and Laboratory Technologies of Samara State Medical University, Ministry of Health of Russia
Abstract
Cardiotoxicity of anticancer therapy is a severe adverse cardiovascular event affecting the survival of cancer patients. Modern methods for diagnosing cardiotoxicity allow to identify already occurred myocardial transformations, accompanied by symptoms of heart failure and are not predict and detect early changes in the heart tissue during treatment. Recently, increasing attention is paid to the search for molecular genetic markers, a single identification of which before starting treatment will make possible to determining the risks of cardiotoxicity and change treatment taking into account individual genetic characteristics. At the same time, most research on the effect of allelic variants of genes on cardio-vascular complications relate to chemotherapy of solid tumors. The review considered possible prognostic genetic variants of cardiotoxicity induced by chemotherapy in patients with the hematopoietic and lymphatic malignancies.
Publisher
Publishing House ABV Press
Subject
Cancer Research,Biochemistry (medical),Genetics (clinical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Reference54 articles.
1. Deo S.V.S., Sharma J., Kumar S. GLOBOCAN 2020 report on global cancer burden: challenges and opportunities for surgical oncologists. Ann Surg Oncol 2022;29(11):6497–500. DOI: 10.1245/s10434-022-12151-6
2. The state of oncological care to the population of Russia in 2021. Ed. by A.D. Kaprin, V.V. Starinskii, A.O. Shakhzadova. Мoscow: P.A. Herzen Institute of Medical Research – branch of the Federal State Budgetary Institution “NMIC of Radiology” of the Ministry of Health of Russia, 2022. 239 p. (In Russ.).
3. Yandieva R.A., Saribekyan E.K., Mamedov M.N. Cardiotoxicity of cancer therapy. Mezhdunarodnyj zhurnal serdca i sosudistyh zabolevanij = International Journal of Heart and Vascular Diseases 2018;6(17):3–11. (In Russ.).
4. Kuzmina T.P., Davydkin I.L., Tereshina O.V. et al. Cardiotoxicity and methods of its diagnosis in hematological patients (literature review). Sibirskij nauchnyj medicinskij zhurnal = Siberian Scientific Medical Journal 2019;39(1):34–42. (In Russ.). DOI: 10.15372/SSMJ20190105
5. Vitsenia M.V., Ageev F.T., Giliarov M.Yu. et al. Practical recommendations for the correction of cardiovascular toxicity of antitumor drug therapy. Zlokachestvennye opuholi: Prakticheskie rekomendacii RUSSCO = Malignant Tumors: Practical Recommendations RUSSCO 2021;11(41):66–87. (In Russ.). DOI: 10.18027/2224-5057-2021-11-3s2-41