Affiliation:
1. N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department
2. N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department;
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Abstract
Treating traumatic spinal cord injuries is one of the most complicated and relevant problems in the modern medicine. In the vast majority of cases spinal cord injury (SCI) leads to persistent disability, with medical, social and economic consequences ensuing for the patient, the family and the state. Modern SCI therapy has a very limited effectiveness and does not allow to sufficiently restore the lost functions of central nervous system. Regenerative methods and particularly cell therapy are very promising to effectively treat SCI. The review highlights SCI epidemiological and pathogenetic problems, existing therapy, as well as promising methods of regenerative therapy. We emphasize the results of preclinical and clinical studies in the field of cell therapy. The review is divided into 4 parts. In the part 3, the description of cell therapy methods continues.Conflict of interest. The authors declare no conflict of interest.
Publisher
Publishing House ABV Press
Reference66 articles.
1. Gage F.H. Mammalian neural stem cells. Science 2000;287(5457):1433–8. DOI: 10.1126/science.287.5457.1433.
2. Lu P., Jones L.L., Snyder E.Y., Tuszynski M.H. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol 2003;181(2):115–29. DOI: 10.1016/s0014-4886(03)00037-2.
3. Cao Q.-L., Zhang Y.P., Howard R.M. et al. Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage. Exp Neurol 2001;167(1):48–58. DOI: 10.1006/exnr.2000.7536.
4. Shihabuddin L.S., Horner P.J., Ray J., Gage F.H. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci 2000;20(23):8727–35.
5. Bottai D., Madaschi L., Di Giulio A.M., Gorio A. Viability-dependent promoting action of adult neural precursors in spinal cord injury. Mol Med 2008;14(9–10): 634–44. DOI: 10.2119/2008-00077. Bottai.