REGENERATIVE TREATMENT OF SPINAL CORD INJURY. LITERATURE REVIEW. PART 1-Reference-Cited by-同舟云学术

REGENERATIVE TREATMENT OF SPINAL CORD INJURY. LITERATURE REVIEW. PART 1

Published:2019-06-16 Issue:2 Volume:21 Page:66-75
ISSN:2587-7569
Container-title:Russian journal of neurosurgery
language:
Short-container-title:Nejrohirurgiâ (Mosk.)

Author:

Smirnov V. А.¹^ORCID,Grin А. А.²^ORCID,Krylov V. V.²

Affiliation:

1. N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department

2. N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department; A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Abstract

Treating traumatic spinal cord injuries is one of the most complicated and relevant problems in the modern medicine. In the vast majority of cases spinal cord injury (SCI) leads to persistent disability, with medical, social and economic consequences ensuing for the patient, the family and the state. Modern SCI therapy has a very limited effectiveness and does not allow to sufficiently restore the lost functions of central nervous system. Regenerative methods and particularly cell therapy are very promising to effectively treat SCI. The review highlights SCI epidemiological and pathogenetic problems, existing therapy, as well as promising methods of regenerative therapy. We emphasize the results of preclinical and clinical studies in the field of cell therapy. The review is divided into 4 parts. Part 1 describes SCI epidemiology and pathogenesis as well as its surgical, physical and pharmacological treatment.

Publisher

Publishing House ABV Press

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