Affiliation:
1. Kazan State Medical University, Ministry of Health of Russia
Abstract
Deep brain stimulation (DBS) involves implantation of electrodes in the basal ganglia of the brain. Dysregulation of neuronal activity in these structures is the cause of motor disorders. DBS is used in many motor (Parkinson’s disease, essential tremor, dystonia, ticks, tardive dyskinesia and others), psychological, behavioral and affective (depression, obsessive-compulsive disorder, epilepsy and others) disorders, as well as in severe pain syndromes resistant to drug therapy. However, the mechanisms of action of DBS are not fully understood. Currently, different theories and hypotheses are considered which explain its mechanism of treatment: rate model, “jamming” theory, hypotheses about the effect on neurogenesis, astrocyte activity, increased brain circulation, electrotaxis, etc.
Publisher
Publishing House ABV Press
Reference69 articles.
1. Martinez-Ramirez D., Hu W., Bona A.R. et al. Update on deep brain stimulation in Parkinson’s disease. Transl Neurodegener 2015;4:12. DOI: 10.1186/s40035-015-0034-0.
2. Zalyalova Z.A., Shabalov V.A. Neirokhirurgicheskoe lechenie bolezni Parkinsona v voprosakh i otvetakh. Metodicheskoe posobie. Kazan', 2008. 24 s. [Zalyalova Z.A, Shabalov V.A. Neurosurgical treatment of Parkinson’s disease: questions and answers. Methodological guide. Kazan, 2008. 24 p. (In Russ.)].
3. Reynolds E. Todd, Faraday and the electrical basis of brain activity. Pract Neurol 2007;7(5):331–5. DOI: 10.1136/jnnp.2007.129023.
4. Benabid A.L., Pollak P., Louveau A. et al. Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl Neurophysiol 1987;50(1–6):344–6. DOI: 10.1016/S0090-3019(97)00459-X.
5. Ekstrapiramidnye rasstroistva. Rukovodstvo po diagnostike i lecheniyu. Pod red. V.N. Shtoka, I.A. Ivanovoi-Smolenskoi, O.S. Levina. M.: MEDpress-inform, 2002. 606 s. [Extrapyramidal disorder. Guidelines for diagnosis and treatment. Ed. by V.N. Shtock, I.A. Ivanova-Smolenskaya, O.S. Levin. Moscow: MEDpress-inform, 2002. 606 p. (In Russ.)].
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