Biological rationale for a patient-specific approach in the treatment of breast cancer. Clinical value of novel biomarkers of breast cancer

Author:

Paltuev R. M.1ORCID

Affiliation:

1. N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia

Abstract

Breast cancer, being the most common type of malignant diseases, remains a significant challenge for both clinicians and fundamental researchers. The implementation of screening mammography, as well as adjuvant and neoadjuvant systemic therapy has made a significant progress in tackling the disease. The studies aimed at the assessment of novel biomarkers of breast cancer, alternative to standard ones, are becoming increasingly relevant. A number of new markers, such as p53, CK5/6, SMA, p63, PHH3, E-cadherin, EGFR, FOXA1, androgen receptors, TILs etc., have demonstrated their high predictive and/or prognostic value in multiple studies. New findings suggest that evaluation of novel biomarkers in breast cancer requires further thorough analysis.Recent studies have identified the role of biomarkers in choosing an optimal treatment strategy for breast cancer, estimated the prognostic value of biomarkers associated with tumor proliferative activity (including cyclin D1, G1-cyclin-dependent kinases 4 and 6, and cyclin-dependent kinases 8/19), specified the role of phospho-histone H3 (which is a proliferation marker that can be used to determine tumor grade), and evaluated the prognostic value of androgen receptors and other biomarkers. Multiple studies have also analyzed the expression of various biomarkers and their impact on overall and relapse-free survival.

Publisher

Publishing House ABV Press

Subject

Pharmacology (medical),Obstetrics and Gynaecology,Radiology Nuclear Medicine and imaging,Oncology,Surgery

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Prognostic value of FOXA1 in patients with Т1–2N0M0 breast cancer;Tumors of female reproductive system;2023-08-05

2. Expression of e- and n-cadherins in tumor in luminal, primary operable breast cancer without her2/neu overexpression in postmenopausal women as a prognostic factor;Research and Practical Medicine Journal;2020-12-22

3. Brachytherapy in comprehensive treatment of breast cancer;Український радіологічний та онкологічний журнал;2020-06-25

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