Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus-Reference-Cited by-同舟云学术

Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus

Published:2023-04-29 Issue:4 Volume:18 Page:138-146
ISSN:1999-8627
Container-title:Tumors of female reproductive system
language:
Short-container-title:Opuholi ženskoj reproduktivnoj sistemy

Author:

Tyulyandina A. S.¹^ORCID,Ulrikh E. A.²^ORCID,Kolomiets L. A.³^ORCID,Krasilnikov S. E.⁴,Kedrova A. G.⁵^ORCID,Rumyantsev A. A.⁶^ORCID,Raskin G. A.⁷^ORCID,Nesterova A. I.⁸^ORCID,Volkonskiy M. V.⁹^ORCID,Churuksaeva O. N.³^ORCID,Goryainova A. Yu.¹⁰^ORCID,Zhavoronkova V. V.¹¹^ORCID,Dmitriev V. N.¹²^ORCID,Nazranova S. T.¹³,Shkradyuk A. V.¹⁴,Volkova K. S.¹⁵,Arutyunova A. I.¹⁶,Kunitskaya S. N.¹⁴,Stepura L. V.¹⁷^ORCID,Zolotoreva T. G.¹⁵,Shakhnovich E. B.¹⁸,Ponomareva E. V.¹⁴,Strokova M. A.¹⁴,Danilova A. S.⁹,Martynova E. S.¹⁹

Affiliation:

1. N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

2. N.N. Petrov National Medical Research Institute of Oncology, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

3. Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences

4. Institute of Oncology and Neurosurgery, E.N. Meshalkin National Medical Research Center, Ministry of Health of Russia

5. Department of Oncology, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian Federation; Department of Obstetrics and Gynecology, Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian Federation

6. N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

7. Saint Petersburg State University; Medical and Diagnostic Center of S. Berezin International Institute of Biological Systems

8. Republican Clinical Oncology Dispensary, Ministry of Health of the Republic of Tatarstan; Kazan Federal University

9. Moscow City Oncology Hospital No. 62, Moscow Healthcare Department

10. Clinical Oncology Dispensary No. 1; Kuban State Medical University

11. Volgograd Regional Clinical Oncology Dispensary; Volgograd State Medical University, Ministry of Health of Russia

12. Belgorod National Research University; Belgorod Oncology Dispensary

13. Oncology Dispensary, Ministry of Health of Kabardino-Balkar Republic

14. V.M. Efetov Crimean Republican Oncology Clinical Dispensary

15. Samara Regional Clinical Oncology Dispensary

16. Pyatigorsk Regional Oncology Dispensary

17. Oncology Dispensary in Shakhty

18. Korolev City Hospital

19. A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary

Abstract

Deficient DNA mismatch repair (dMMR) is a rare molecular disorder found in 20-30 % of endometrial tumors. Laboratory identification of dMMR/microsatellite instability (MSI) has a high diagnostic value, since these impairments are considered as biomarkers of endometrial adenocarcinoma. They help to identify patients at high risk of Lynch syndrome, evaluate the disease prognosis, and estimate the efficacy of immune checkpoint inhibitors and their combinations. This review details current concepts of MSI diagnostics and discusses its predictive value in patients with endometrial cancer. It also describes a new diagnostic algorithm for the detection of dMMR and MSI.

Publisher

Publishing House ABV Press

Subject

Pharmacology (medical),Obstetrics and Gynecology,Radiology, Nuclear Medicine and imaging,Oncology,Surgery

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