Kikuchi–Fujimoto disease: literature review and report of four cases

Author:

Potapenko V. G.1ORCID,Baykov V. V.2ORCID,Markova А. Yu.3,Mikhailova N. B.2ORCID,Ter‑Grigoryan A. S.4,Krivolapov Yu. А.5ORCID

Affiliation:

1. City Clinical Hospital No. 31

2. Raisa Gorbacheva Memorial Research Institute for Pediatric Oncology, Hematology and Transplantation, I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia

3. City Hospital of the closed territorial unit Znamensk

4. Hematological Center named after professor R.O. Yeolyan, Ministry of Health of the Republic of Armenia

5. I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

Abstract

Kikuchi–Fujimoto disease, or necrotizing histiocytic lymphadenitis, is one of the rare causes of benign lymphadeno-pathy. The diagnosis is based on histological and immunohistochemical analysis of the lymph node biopsy. The article presents four clinical cases of Kikuchi–Fujimoto disease. According to the results of the primary analysis of lymph node tissue three patients were misdiagnosed with lymphoma. due to the unusual for lymphoid malignancy course the primary material was reviewed. The diagnosis of Kikuchi–Fujimoto disease was put. In three patients the disease has a re-current course. during the observation period, the course of the disease in all the presented patients is benign with normal quality of life.

Publisher

Publishing House ABV Press

Subject

Oncology,Hematology

Reference49 articles.

1. Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis: a clinicopathological study. Acta Hematol Jpn 1972;(35):379–80.

2. Fujimoto Y., Kojima Y., Yamaguchi K. Cervical subacute necrotizing lymphadenitis. A new clinicopathological entity. Naika 1972;(20):920–7.

3. Dumas G., Prendki V., Haroche J. et al. Kikuchi–Fujimoto disease: retrospective study of 91 cases and review of the literature. Medicine (Baltimore) 2014;93(24):372–82. DOI: 10.1097/MD. 0000000000000220

4. Tanaka T., Ohmori M., Yasunaga S. et al. DNA typing of HLA class II genes (HLA­DR, ­DQ and ­DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi’s disease). Tissue Antigens 1999;54(3):246–53. DOI: 10.1034/j.1399­0039.1999.540305.x

5. Lukmanova L.Z., Tyurin A.V. Kikuchi–Fujimoto lymphadenitis in the onset of systemic lupus erythematosus. Klinitsist = The Clinician 2018;12(1):81–2. (In Russ.).

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