RECONSTITUTION OF B-CELLS IMMUNITY AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION-Reference-Cited by-同舟云学术

RECONSTITUTION OF B-CELLS IMMUNITY AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

Published:2020-06-18 Issue:2 Volume:19 Page:22-30
ISSN:1726-9792
Container-title:Russian Journal of Biotherapy
language:
Short-container-title:Rossijskij bioterapevtičeskij žurnal

Author:

Chulkova S. V.¹^ORCID,Subbotina N. N.²,Petrova G. D.³,Sidorova N. V.³^ORCID,Kolbatskaya O. P.³^ORCID,Tupitsyn N. N.³^ORCID,Nurtazinа A. Yu.⁴^ORCID

Affiliation:

1. N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation; N.I. Pirogov Russian National Research Medical University

2. Clinical Hospital “MEDSI”

3. N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

4. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Abstract

The restoration of B-cell immunity is a key component of the success of allogeneic hematopoietic stem cell transplantation. In most cases, the restoration of B-lymphopoiesis is a slow and often incomplete process, which is accompanied by a decrease in the tolerance of the recipient to bacterial, viral, fungal pathogens. This process is influenced by a number of factors that determine its effectiveness and pace. It is important to restore not only the size of the B-cell population, but also their functional usefulness. The article provides an analysis of modern literature data on the significance of the restoration of B-cell immunity after allogeneic hematopoietic stem cell transplantation, a review of the main factors affecting the process of B-lymphopoiesis, and their prognostic component.

Publisher

Publishing House ABV Press

Reference54 articles.

1. Young J.H., Logan B.R., Wu J. et al. Infections after transplantation of bone marrow or peripheral blood stem cells from unrelated donors. Biol Blood Marrow Transplant 2016;22(2):359–70. DOI: 10.1016/j.bbmt.2015.09.013.

2. Pasquini M.C., Zhu X. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR Summary Slides, 2015. Available by: http://www.cibmtr.org.

3. Socie G., Stone J.V., Wingard J.R. et al. Long-term survival and late deaths after allogeneic bone marrow transplantation. Late effects working committee of the international bone marrow transplant registry. N Engl J Med 1999;341:14–21. DOI: 10.1056/NEJM199907013410103.

4. Eapen M., Rocha V., Sanz G. et al. Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. Lancet Oncol 2010;11:653–60. DOI: 10.1016/S1470-2045(10)70127-3.

5. Parody R., Martino R., Rovira M. et al. Severe infections after unrelated donor allogeneic hematopoietic stem cell transplantation in adults: comparison of cord blood transplantation with peripheral blood and bone marrow transplantation. Biol Blood Marrow Transplant 2006;12:734–48. DOI: 10.1016/j. bbmt.2006.03.007.