PAPILLOMAVIRAL CARCINOGENESIS. MAJOR ACHIEVEMENTS AND CERTAIN CHALLENGES PART I. GENERAL NOTIONS OF PAPILLOMAVIRUSES. HUMAN PAPILLOMAVIRUSES-ASSOCIATED CANCERS

Abstract

Development of three vaccines intended to prevent cervical cancer (CC) caused by oncogenic human papillomaviruses (HPV) appears to be principal result of research into papillomaviral carcinogenesis. Two of these vaccines efficient in prophylaxis of about 70 % of new CC cases have been recommended for application in Russia. Up till now preventive HPV-vaccinations are not included into the Russian National Vaccination Shedule. In addition to CC HPV are known as etiological agents of some other anogenital as well as certain head and neck tumors. The overall cancer statistics data are found to vary owing to socioeconomic inequalities extremely dramatically for the most preventable cancers. The review is dedicated to major achievements and certain challenges in the field of oncogenic HPV studies.