The role of the renin-angiotensin system in the appearance and progression of renal cell carcinoma: a literature review-Reference-Cited by-同舟云学术

The role of the renin-angiotensin system in the appearance and progression of renal cell carcinoma: a literature review

Published:2019-10-09 Issue:3 Volume:15 Page:143-149
ISSN:1996-1812
Container-title:Cancer Urology
language:
Short-container-title:Onkourologiâ

Author:

Kogan M. I.¹^ORCID,Akhokhov Z. M.²^ORCID,Chernogubova E. A.³^ORCID,Gusev A. A.⁴^ORCID,Oitova Z. Kh.⁵^ORCID

Affiliation:

1. Rostov State Medical University, Ministry of Health of Russia; Federal Research Center the Southern Scientific Center of the Russian Academy of Sciences

2. Emergency Aid City Hospital

3. Federal Research Center the Southern Scientific Center of the Russian Academy of Sciences

4. Rostov State Medical University, Ministry of Health of Russia

5. Kh.M. Berbekov Kabardino-Balkarian State University

Abstract

Renal cell carcinoma (RCC) is one of the most common forms of malignant epithelial tumors of this localization. The development of new approaches to the diagnosis, prognosis and treatment of RCC is an topical issue of molecular medicine. The renin-angiotensin system (RAS) is not only an important component of the central and humoral mechanisms of controlling blood pressure and hydroelectrolytic balance, but also refers to the body systems involved in complex carcinogenesis pathways. Researches on the role of RAS in tumor progression are currently the priority. The data on the role of RAS in the development and progression of malignant tumors in the kidneys are being discussed. In this article, we present an overview of data on the role of RAS in the emergence and development of RCC, an analysis of the molecular mechanisms of development and progression of RCC, the prospects for using indicators of the RAS: angiotensin-converting enzymes (ACE), ACE2 and angiotensin II receptors as markers of diagnosis and monitoring of neoplastic transformation processes in the kidney. The prospects for the use of new, effective anticancer drugs with a targeted effect on definite indicators of the RAS of RCC were analyzed.

Publisher

Publishing House ABV Press

Subject

Urology,Nephrology,Radiology, Nuclear Medicine and imaging,Oncology,Surgery

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