Quinazolinon derivatives for the treatment of neoplastic, parasitic and neurodegenerative diseases-Reference-Cited by-同舟云学术

Quinazolinon derivatives for the treatment of neoplastic, parasitic and neurodegenerative diseases

Published:2017-09-30 Issue:3 Volume:16 Page:32-42
ISSN:1726-9784
Container-title:Russian Journal of Biotherapy
language:
Short-container-title:Rossijskij bioterapevtičeskij žurnal

Author:

Khachatryan D. S.¹,Misyurin V. A.²,Baryshnikova M. A.³,Golubtsova N. V.²,Kolotaev A. V.¹,Matevosyan K. R.⁴

Affiliation:

1. Institute of Chemical Reagents and High Purity Chemical Substances (IREA)

2. N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

3. Institute of Chemical Reagents and High Purity Chemical Substances (IREA); N.N. Blokhin Russian Cancer Research Center

4. Dmitry Mendeleev University of Chemical Technology of Russia

Abstract

In this review we discuss some biological activities of quinazolinon derivatives. The derivatives of quinazolinon possess their activity by binding to some proteins important for the survival, proliferation and metastasis of tumor cells. There are grounds to initiate clinical trials of these substances to create new treatment protocols for a wide range of cancer diseases, several parasitic diseases, and certain neurodegenerative diseases.

Publisher

Publishing House ABV Press

Reference70 articles.

1. Alaimo R.J., Russell H.E. Antibacterial 2.3-dihydro-2-(5-nitro-2-thienyl) - quinazolin-4(1H) - ones. J Med Chem 1972;15(3):335-6. PMID: 4621761.

2. Bonola G., Da Re P., Magistretti M.J. et al. 1-aminoacyl-2,3-dihydro-4(1H) - quinazolinone derivatives with choleretic and antifibrillatory activity. J Med Chem 1968;11(6):1136-9. PMID: 5680025.

3. Levin J.I., Chan P.S., Bailey T. et al. The synthesis of 2,3-dihydro-4(1H) - quinazolinone angiotensin II receptor antagonists Bioorg. Med Chem Lett 1994;4:1141-6.

4. Okumura K., Oine T., Yamada Y. et al. 4-oxo-1,2,3,4-tetrahydroquinazolines. I. Syntheses and pharmacological properties of 2-methyl-3-aryl-4-oxo- 1,2,3,4-tetrahydroquinazolines and their 1-acyl derivatives. J Med Chem 1968;11(2):348-52. PMID: 4385706.

5. Neil G.L., Li L.H., Buskirk H.H., Moxley T.E. Antitumor effects of the antispermatogenic agent, 2.3-dihydro-2-(1-naphthyl) - 4(1H) - quinazolinone(NSC-145669). Cancer Chemother Rep 1972;56(2):163-73. PMID: 5043224.