Sleep disorder in Angelman syndrome: causes, mechanisms and methods of correction. Literature review

Author:

Psyanchin A. A.1,Bobylova M. Yu.2ORCID,Yakupov T. Z.1

Affiliation:

1. Clinical Hospital “Mother and Child”

2. Svt. Luka’s Institute of Child Neurology and Epilepsy; Svt. Luka’s Institute of Pediatric and Adult Neurology and Epilepsy

Abstract

Sleep disorder is one of the prominent manifestations of Angelman syndrome. The exact causes are unknown and methods of correction are difficult. The literature review is devoted to studies of the pathogenesis of sleep disorders in Angelman syndrome (the effects of gene function in 15q11–q13 deletion, findings in polysomnography, video-EEG sleep monitoring, laboratory data), on the basis of which recommendations for the correction of dyssomnia, including methods of behavioral therapy, are given.

Publisher

Publishing House ABV Press

Subject

Neurology (clinical),Pediatrics, Perinatology and Child Health

Reference40 articles.

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2. Kuzmich G.V., Bobylova M.Yu., Mukhin K.Yu. et al. EEG in Angelman syndrome. Notched slow waves and age-specific characteristics of the main EEG patterns. Russkiy zhurnal detskoy nevrologii = Russian Journal of Child Neurology 2021;16(1–2):42–57. (In Russ.)

3. Mikhailova N.V., Savinov S.V., Akchurina Ya.E. et al. Angelman syndrome as an illustration of a differentiated approach to the diagnosis of the causes of autism, psychomotor retardation and cerebral palsy. Neyrokhirurgiya i nevrologiya Kazakhstana = Neurosurgery and Neurology of Kazakhstan 2017;1(46):60–4. (In Russ.)

4. Allen K.D., Kuhn B.R., DeHaai K.A., Wallace D.P. Evaluation of a behavioral treatment package to reduce sleep problems in children with Angelman syndrome. Res Dev Disabil 2013;34(1):676–86. DOI: 10.1016/j.ridd.2012.10.001

5. Braam W., Didden R., Smits M.G., Curfs L.M. Melatonin for chronic insomnia in Angelman syndrome: a randomized placebocontrolled trial. J Child Neurol 2008;23(6):649–54. DOI: 10.1177/0883073808314153

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