Efficienc y of vag us nerve stim ulation in epilepsy (literat ure review and case report )

Author:

Pylaeva O. A.1,Chadaev V. A.2,Bobylova M. Yu.1,Mukhin K. Yu.1ORCID

Affiliation:

1. Svt. Luka’s Institute of Child Neurology and Epilepsy; Svt. Luka’s Institute of Child and Adult Neurology and Epilepsy

2. Svt. Luka’s Institute of Child and Adult Neurology and Epilepsy

Abstract

Despite significant advances in epileptology, approximately one-third of patients suffer from drug-resistant epilepsy. Numerous approaches are currently available to treat epilepsy; however, there are still many patients with treatment-resistant epilepsy, in whom antiepileptic drugs are ineffective and surgical treatment is impossible. Thus, searching for new effective antiepileptic drugs and alternative treatments (such as vagus nerve stimulation) for these patients remains highly relevant. This literature review covers the indications for and the efficacy and tolerability of vagus nerve stimulation in patients with epilepsy. We also report a case of successful treatment of a patient with drug-resistant epilepsy using this method.

Publisher

Publishing House ABV Press

Subject

Clinical Neurology,Pediatrics, Perinatology, and Child Health

Reference75 articles.

1. Ayvazyan S.O. Surgical treatment of epilepsy in children: indications, issues of pre-surgical examination. Moscow, 2017. Pp. 19–25. (In Russ.).

2. Areshkina I.G., Dmitrenko D.V., Shnayder N.A., Narodova E.A. The efficacy and safety of vagus nerve stimulation in patients with pharmacoresistant epilepsy. Epilepsiya i paroksizmalnye sostoyaniya = Epilepsy and paroxysmal states 2019;11(1):27–36. (In Russ.). DOI: 10.17749/2077-8333.2019.11.1.27-36.

3. Karlov V.A. Epilepsy in children and adults, women and men. Moscow: Binom, 2019. Pp. 837–858. (In Russ.).

4. Lipatova L.V., Skoromets T.A., Gromov S.A. et al. Experience in the use of stimulation of the vagus nerve in the treatment of pharmacoresistant epilepsy. Nevrologiya, neyropsikhiatriya, psikhosomatika = Neurology, neuropsychiatry, psychosomatics 2014;6(1S):18–21. (In Russ.). DOI: 10.14412/2074-2711-2014-1S-18-21.

5. Aldenkamp A., Besag F., Gobbi G. et al. Psychiatric and behavioural disorders in children with epilepsy (ILAE Task Force Report): adverse cognitive and behavioral effects of antiepileptic drugs in children. Epileptic Disord 2016. DOI: 10.1684/epd.2016.0817.

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