Molecular, biological and diagnostic features of Ewing sarcoma and undifferentiated small round cell sarcomas of bone and soft tissue-Reference-Cited by-同舟云学术

Molecular, biological and diagnostic features of Ewing sarcoma and undifferentiated small round cell sarcomas of bone and soft tissue

Published:2021-06-03 Issue:1 Volume:13 Page:24-31
ISSN:2219-4614
Container-title:Bone and soft tissue sarcomas, tumors of the skin
language:
Short-container-title:jour

Author:

Sinichenkova K. Y.¹^ORCID,Roschin V. Y.¹^ORCID,Druy A. E.¹^ORCID

Affiliation:

1. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology, Ministry of Healh of Russia

Abstract

Ewing’s sarcoma is a highly malignant small round cell tumor with a unique rearrangement of the EWSR1 (FUS) gene with partners genes of ETS family. Tumors with Ewing's sarcoma morphological features lacking without specific EWSR1 rear-rangement called undifferentiated small round cell sarcomas of bone and soft tissue. This group includes: sarcomas with СIC gene rearrangement, sarcomas with BCOR gene rearrangement and sarcomas with EWSR1 (FUS) gene rearrangement with non-ETS gene-partner. Clinical, morphological and molecular genetic characteristics of these groups of tumors will be described below

Publisher

Publishing House ABV Press

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