Affiliation:
1. RUDN University; P.A. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre
2. RUDN University
3. A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
4. Research Centre for Medical Genetics; N.I. Pirogov Russian National Research Medical University
Abstract
Peyronie’s disease (PD) is a benign fibrous lesion in the albuginea of the penis that can occur in men of various ages. Despite the fact that epidemiological and pathophysiological data on PD are contradictory, there are a number of comorbidities that suggest a genetic predisposition to this pathology. Genetic and molecular studies of PD are insufficient and their results are often contradictory. This literature review will consider the most studied and potential genetic predictors of PD, namely: transforming growth factor β1, myostatin, matrix metalloproteinases, Wnt signaling pathway, microRNAs (MiR-29b), major histocompatibility complex proteins (human leukocyte antigen). Expanding the possibilities of early diagnosis of the disease will increase the effectiveness of the treatment.
Publisher
Publishing House ABV Press
Subject
Urology,Reproductive Medicine,Surgery