Overall and relapse-free survival of dogs with appendicular osteosarcoma after limb-sparing bio-implantation treatment-Reference-Cited by-同舟云学术

Overall and relapse-free survival of dogs with appendicular osteosarcoma after limb-sparing bio-implantation treatment

Published:2023-12-12 Issue:4 Volume:15 Page:33-39
ISSN:2782-3687
Container-title:Bone and soft tissue sarcomas, tumors of the skin
language:
Short-container-title:jour

Author:

Kornyushenkov E. A.¹,Mitrushkin D. E.¹^ORCID,Garanin D. V.²^ORCID,Kuznetsova A. L.¹^ORCID,Fateeva E. A.¹^ORCID,Kiselevsky M. V.³^ORCID,Anisimova N. Yu.⁴^ORCID,Zakharov E. V.¹^ORCID,Shimshirt A. A.¹^ORCID

Affiliation:

1. Clinic of Experimental Therapy of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia; Veterinary Сlinic “Biocontrol”

2. Veterinary Сlinic “Biocontrol”

3. Cell Immunity Laboratory of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia

4. Clinic of Experimental Therapy of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russia

Abstract

Introduction. Canine osteosarcoma is a most common bone tumor in dogs, usually involving long tubular bones lesion. Limb-sparing treatment method allows to save extremity functionality and sufficiently improve quality of life in comparison with amputation.Aim. To analyze the survival rates and local results after limb-sparing treatment of canine osteosarcoma using bio-implantation – de-immunized allogenic bone populated with recipient stromal mesenchymal cell preparation.Materials and methods. Group of 25 dogs underwent a combined treatment including cisplatinum chemotherapy (60–70 mg/m2 intravenously infusion at 14–21 day intervals, up to 4 cycles) and wide segmental resection of the affected bone with a bioimplant defect replacement. Overall survival, progression-free survival and local recurrence frequency in the group were analyzed.Results. Overall survival median was 321 day, and progression-free median was 222 days. 4 (16,6 %) cases of local relapse were recorded, 2 of which were confirmed by radiography and histological examination, and 2 other by radiography only.Conclusion. Efficiency of the canine appendicular osteosarcoma combined limb-sparing treatment is comparable with amputation practice results (according to scientific literature) while foregoing method is preferable due to higher life quality of patients.

Publisher

Publishing House ABV Press

Reference11 articles.

1. Mitchell K.E., Boston S.E., Kung M. et al. Outcomes of limb-sparing surgery using two generations of metal endoprosthesis in 45 dogs with distal radial osteosarcoma. A Veterinary Society of Surgical Oncology retrospective study. Vet Surg 2016;45(1):36–43. DOI: 10.1111/vsu.12423

2. MacDonald T.L., Schiller T.D. Limb-sparing surgery using tantalum metal endoprosthesis in a dog with osteosarcoma of the distal radius. Can Vet J 2010;51(5):497–500.

3. Jehn C., Farese J., Lewis D. et al. Current treatment options for dogs with appendicular osteosarcoma. Vet Med 2005;100:295–305.

4. Gassel A., Bilbrey S. Limb-sparing surgery for appendicular osteosarcoma in dogs. Vet Med 2003;8:119–24.

5. Morello E., Buracco P., Martano M. et al. Bone allografts and adjuvant cisplatin for the treatment of canine appendicular osteosarcoma in 18 dogs. J Small Anim Pract 2001;42(2):61–6. DOI: 10.1111/j.1748-5827.2001.tb01993.x