Influence of Powerful Non-Ionizing Terahertz Radiation on Healthy and Tumor Human Cells of Neural Origin-Reference-Cited by-同舟云学术

Influence of Powerful Non-Ionizing Terahertz Radiation on Healthy and Tumor Human Cells of Neural Origin

Published:2021-11-02 Issue:5 Volume:66 Page:5-10
ISSN:1024-6177
Container-title:Medical Radiology and radiation safety
language:en
Short-container-title:

Author:

Shatalova R.¹,Gurova S.¹,Revkova V.²,Ilina I.³,Sitnikov D.³

Affiliation:

1. National Research Nuclear University, MEPhi Obninsk Institute for Nuclear Power Engineering, Obninsk, Russia

2. Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Moscow, Russia

3. Joint Institute for High Temperatures, Moscow, Russia

Abstract

Purpose: Study of the influence of high-power pulses of coherent non-ionizing terahertz (THz) radiation on the formation of foci of double-strand DNA breaks and the proliferative activity of human neuronal cells. Material and methods: Irradiated cell cultures are direct reprogramming neural progenitor cells (drNPCs), neuroblastoma cells (SK-N-BE). Cells are irradiated with a sequence of THz radiation pulses with a peak intensity of ~ 20 GW/cm2 and electric field strength of 2.8 MV/cm. Irradiation lasts 30 mins. Results: There is no statistically significant difference in the number of γH2AX histone foci between experimental and control cell groups. Conclusion: It was shown that a short exposure (30 min) of cells to THz radiation with intensity of 20 GW/cm2 does not affect the proliferative activity of both neural progenitor cells and neuroblastoma cells and does not cause a significant increase in γH2AX foci in any of the studied cell lines.

Publisher

Infra-M Academic Publishing House

Subject

Nuclear Energy and Engineering

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