Morphological Peculiarities of the Behaviour of Hemostatic Drug "SERGISEL Fibrillar" in the Treatment of Piercing Wounds Liver

Abstract

The experiment was carried out on 21 mongrel dogs. The authors studied the morphological changes in the liver after introduction of a pass-through stab wound hemostatic preparation new generation " Sergisel Fibrillar " and cryo-application the mouth of the wound channel to secure the preparation and amplification hemostatic effect. During observation from 1 to 30 days it is established gradually wound healing and formation of liver damage in the area of fine connective tissue scar. After the use of the "Sergisel fibrillar" as a foreign object, standard morphological response in the form of a purulent inflammation and proliferation of connective tissue are developed. These processes are broken off and around the fibers don’t develop abscess, because resorption of fiber hemostatic agents occurs in a short time. The results of the end of the experimental observation were the followings: regenerative processes in liver parenchyma increasing, particularly in the area of damage and are shown restoration of the girder structure of the liver, the disappearance of oedema and plethora. It indicates the recovery of liver tissue after applying the proposed method.