Management of pregnant women with undifferentiated connective tissue dysplasia

Abstract

The purpose of this study was to develop complex diagnostic and corrective measures during pregnancy in women with undifferentiated connective tissue dysplasia. Material and Subjects: the research object was 380 women who were treated in Tula regional perinatal centre and Maternity hospital №1 of Tula with signs of undifferentiated connective tissue dysplasia during 2008- 2010 yy., and as a comparison group 45 women in the absence of signs of dysplasia in the same time period. To assess the magnesium therapy effectiveness, the women of experimental group were divided into two subgroups (190+190) depending on the use/non-use of the preparation of magnesium with early pregnancy term. Results: undifferentiated connective tissue dysplasia during pregnancy is clinically manifested by neurocirculatory dystonia, vascular disorders and hemorrhagic syndrome, as well as a high frequency of placenta insufficiency, threatened abortion in 1-3 trimesters, isthmic-cervical insufficiency, early toxicosis and anemia of pregnant. The etiological-pathogenetical treatment was resulted in to the improvement of pregnant women health, reduction of the frequency of different complaints and decreased of average weight of these pregnancy complications. Normalization of parameters of oxyproline and magnesium in the blood of pregnant women in 12-22-34 weeks of pregnancy due to magnesium therapy was laboratory confirmed. Conclusion: undifferentiated connective tissue dysplasia during pregnancy contributes to the development of certain pathological conditions of various systems of the body and it can be effectively corrected by magnesium drugs (Magne-B6) under the control of oxyproline and magnesium in the blood of pregnant women. Magnesium therapy ensures the accessibility, quality and efficiency of health prevention activities to women with undifferentiated connective tissue dysplasia that has a significant impact on the effectiveness of antenatal preparation and enhances the quality of life of pregnant women.