A METABOLITE OF PROGESTERONE 11-DEOXYCORTICOSTERONE IN PLACENTA DURING EXACERBATION OF CYTOMEGALOVIRUS INFECTION-Reference-Cited by-同舟云学术

A METABOLITE OF PROGESTERONE 11-DEOXYCORTICOSTERONE IN PLACENTA DURING EXACERBATION OF CYTOMEGALOVIRUS INFECTION

Published:2019-03-25 Issue:71 Volume:1 Page:84-87
ISSN:1998-5029
Container-title:Bulletin physiology and pathology of respiration
language:en
Short-container-title:

Author:

Довжикова Инна¹,Dovzhikova Inna²,Андриевская Ирина¹,Andrievskaya Irina²,Петрова Ксения¹,Petrova Kseniya²,Ишутина Наталия³,Ishutina Nataliya⁴,Гориков Игорь¹,Gorikov Igor²

Affiliation:

1. Дальневосточный научный центр физиологии и патологии дыхания

2. Far Eastern Scientific Center of Physiology and Pathology of Respiration

3. ФГБНУ "Дальневосточный научный центр физиологии и патологии дыхания"

4. FGBNU "Dal'nevostochnyy nauchnyy centr fiziologii i patologii dyhaniya"

Abstract

The aim of the work is to study the content of 11-deoxycorticosterone in the placenta during pregnancy complicated by exacerbation of cytomegalovirus infection. Histochemical method was used to determine the content of 11-deoxycorticosterone in 72 placentas, including 37 cases from women with acute cytomegalovirus infection and simultaneously diagnosed moderate preeclampsia, and 35 placentas from women with exacerbation of chronic cytomegalovirus infection without concomitant diseases. The control group consisted of 30 placentas from mothers with chronic cytomegalovirus infection in the latent stage. It was found out that an increase in the content of 11-deoxycorticosterone in placenta by 25% in comparison with the control group occurred during gestation with an exacerbation of cytomegalovirus infection. A significant increase (by 40%) in the content of this hormone in the placenta was noted during the reactivation of the viral process accompanied by preeclampsia. We believe that an increase in the production of 11-deoxycorticosterone with mineralocorticotropic effect in the placenta could contribute to the development of hypertensive disorders in pregnancy complicated by cytomegalovirus infection.

Publisher

Far Eastern Scientific Center Of Physiology and Pathology of Respiration

Subject

General Medicine

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