PATHOGENETIC FEATURES OF PHENOTYPES OF ASTHMA AT THE RESORT STAGE OF MEDICAL REHABILITATION

Author:

Дудченко Лейла1,Dudchenko Leila2,Беляева Светлана1,Beliaeva Svetlana2,Масликова Галина1,Maslikova Galina2,Ковальчук Станислав1,Koval'chuk Stanislav2,Савченко Валентин3,Savchenko Valentin4

Affiliation:

1. Академический научно-исследовательский институт физических методов лечения, медицинской климатологии и реабилитации им. И.М. Сеченова

2. Academician Research Institute of Physical Methods of Treatment, Medical Climatology and Rehabilitation named after I.M. Sechenov

3. Крымский федеральный университет имени В.И.Вернадского

4. Crimean Federal University of a name of V.I.Vernadsky

Abstract

The aim of the study is to describe pathogenetic features of phenotypes of asthma at a resort stage of medical rehabilitation. 300 patients with asthma who arrived on the Southern coast of the Crimea (Yalta) for medical rehabilitation were examined. As a result of the study 7 phenotypes of asthma at a resort stage of medical rehabilitation were distinguished. Asthma phenotypes created by the cluster analysis are pathological conditions of patients which were caused by different pathogenetic mechanisms. Each phenotype of asthma is characterized only by its peculiar pathogenetic features in the form of the manifestation of a different degree and relation of clinical changes and functional indices of airway obstruction, an allergic (eosinophilic) inflammation, a condition of physical working capacity and the quality of life taking into account the gender of patients, their body weight, an age of a disease debut and features of application of medications. The established pathogenetic mechanisms of each asthma phenotypes can be considered when individual programs of medical rehabilitation at the resort are formed

Publisher

Far Eastern Scientific Center Of Physiology and Pathology of Respiration

Subject

General Medicine

Reference11 articles.

1. Загидулин Ш.З., Галимова Е.С., Суховская О.А., Ежова Г.Ю. Оценка качества жизни у пациентов с обострением бронхиальной астмы // Пульмонология. 2013. №1. С.49–53. doi: http://dx.doi.org/10.18093/0869-0189-2013-0-1-49–53, Zagidullin S.Z., Galimova E.S., Sukhovskaya O.A., Ezhova G.Y. Evaluation of quality of life in patients with asthma exacerbation. Russian Pulmonology 2013; (1):49–53 (in Russian). doi: http://dx.doi.org/10.18093/0869-0189-2013-0-1-49–53

2. Трухачева Н.В. Математическая статистика в медико-биологических исследованиях с применением пакета Statistica. М.: ГЭОТАР-Медиа, 2012. 383 с., Trukhacheva N.V. Mathematical statistics in biomedical research using the Statistica package. Moscow: GEOTAR-Media; 2012 (in Russian).

3. Bel E.N. Clinical phenotypes of asthma // Curr. Opin. Pulm. Med. 2004. Vol.10, №1. Р.44–50., Bel E.N. Clinical phenotypes of asthma. Curr. Opin. Pulm. Med. 2004; 10(1):44–50.

4. Chung K.F., Bel E.H., Wenzel S.E. Difficult-to-Treat Severe Asthma. European Respiratory Society Monograph. 2011. Vol.51. doi: 10.1183/1025448x.erm5110, Chung K.F., Bel E.H., Wenzel S.E. Difficult-to-Treat Severe Asthma. European Respiratory Society Monograph, Vol.51. 2011. doi: 10.1183/1025448x.erm5110

5. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Updated 2012. URL: http://www.ginasthma.org, Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Updated 2012. Available at: www.ginasthma.org

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