Author:
Ким Евгений,Kim Evgenij,Горбачев Владимир,Gorbachev Vladimir,Унжаков Виталий,Unzhakov Vitalij
Abstract
One of the most serious complications of modern anesthesia is malignant hyperthermia, which is a pharmacogenetic
disease phenotype manifested by skeletal muscle hypermetabolism and rhabdomyolysis during or after general anesthe-
sia with the use of inhaled anesthetics and succinylcholine. In Russia, the problem of malignant hyperthermia remains
unresolved. This is mainly due to the fact that the only specific drug dantrolene created for the effective treatment of
malignant hyperthermia is still not legalized and thus formally prohibited to import, disseminate and apply on the
domestic pharmaceutical market. This article deals with the regulatory framework of specific treatment of malignant
hyperthermia in Russia, allowing the possibility to legally import to the territory of the Russian Federation dantrolene
as an unregistered drug, if it is a question of rendering medical assistance on vital indications to a particular patient, or
its unauthorized use for vital indications in a situation of extreme necessity. The article presents the recommendations
of domestic experts on the treatment of malignant hyperthermia. In this case, as a possible alternative to dantrolene,
magnesium preparations are considered, whose role in the treatment of the crisis of malignant hyperthermia continues
to be specified.
Thus, given the increasing use of inhalation anesthesia by Russian anesthetists, to ensure the safety of patients with
regard to the development of malignant hyperthermia, it is possible only in the case of official registration in the do-
mestic dantrolene market. Also, in the territory of Russia, a network of relevant consultative and diagnostic centers
should be established. These measures will undoubtedly increase the effectiveness of treatment and prevention of severe
consequences of this disease in our country.
Publisher
Infra-M Academic Publishing House
Reference1 articles.
1. Ким, Горбачев - хирургия, Kim, Gorbachev - hirurgiya
Cited by
2 articles.
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