Evolving Our Assessment & Future Guiding Principles Workshop Report (2023)

Author:

Osborne Olivia,Mulholland Cath,Wells Sophy,Boobis Alan

Abstract

1.The Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) held a workshop to start work on updating their guidance on toxicity testing and its supporting principles. The starting point for the process is to use existing frameworks and guidance but with the aim of introducing innovative improvements where appropriate. 2.The workshop aimed to identify areas where guidance needs to evolve and included reviewing fundamental risk assessment principles, current guidance on risk assessment and what can be learned from it, integration of new approach methodologies, exploring hazard vs risk and weight of evidence. 3.The overall objective was to discuss how the Committee moves forward in a new era of risk assessment.

Publisher

Food Standards Agency

Reference17 articles.

1. Barlow, S.M., Greig, J.B., Bridges, J.W., Carere, A., Carpy, A.J.M., Galli, C.L., Kleiner, J., Knudsen, I., Koeter, H.B.W.M., Levy, L.S. and Madsen, C., 2002. Hazard identification by methods of animal-based toxicology. Food and Chemical Toxicology, 40(2-3), pp.145-191.

2. Cattaneo, I., Kalian, A.D., Di Nicola, M.R., Dujardin, B., Levorato, S., Mohimont, L., Nathanail, A.V., Carnessechi, E., Astuto, M.C., Tarazona, J.V. and Kass, G.E., 2023. Risk Assessment of Combined Exposure to Multiple Chemicals at the European Food Safety Authority: Principles, Guidance Documents, Applications and Future Challenges. Toxins, 15(1), p.40.

3. COT/ FSA Paving the way for a UK Roadmap: Development, Validation and Regulatory Acceptance of New Approach Methodologies (NAMs) in Chemical Risk Assessment (Draft Version 3) Available at: UK New Approach Methodologies Roadmap (2023) Draft Version 3 | Committee on Toxicity (food.gov.uk)

4. European Food Safety Authority Guidance on the use of the benchmark dose approach in risk assessment. Available at: Guidance on the use of the benchmark dose approach in risk assessment | EFSA (europa.eu)

5. European Food Safety Authority Guidance and other assessment methodology.Available at: Guidance and other assessment methodology documents | EFSA (europa.eu)

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