PROGNOSTIC VALUE OF IMMUNE PREDICTORS OF DIABETIC RETINOPATHY AGAINST THE BACKGROUND OF THE METABOLIC SYNDROME

Abstract

Global statistics of recentyear sindicate a rapidin creasein the in cidence of diabetesamong the population. In thisregard, diabetic retinopathy, the main complication of diabeteson the part of the organ of vision, occupiesone of the leading placesamong the knowncauses o freducedvision and blindness, and the number of cases of visionlossas a result of this complication main tains a steady trend of constant growth. But the most significant and widespreadcause of visionlossin diabetesis pathology of the retina (diabetic retinopathy). The refore, itisrelevantto study immunological predictors for the purpose of time lydiagnosis, prevention of complications and prevention of the development of this disease. Thus, itisclear from the abovethatvariou schemokines and the irreceptors play animportantrolein the pathogenesis of diabetes in humans. The ypartici patein the autoimmune processin the islets of Langerhans of the pancreas, starting from the earlylatenttothe clinical stage of the disease, directing the flow of variousantigen-dependent effector cells from the blood totheinsulitis, whichsecrete a spectrum of pro-inflammatory cytokines, whichlead stoapoptosis and necrosisof β-cells. Atthesametime, inthefuture, in the distantstages of the development of diabetes, chemokines canparticipatein the occurrence of inflammatory complications characteristic of this disease, especiall ymicro- and macro angiopathy: retino- and nephropathy, atherosclerosis and cardiovascular diseases. The existence of such scientific information and fur the study of this issue open upnew wayst ocreate methods of targeted immunotherapy and prevention of diabetes and itscomplications by specific blockade of certainlinks of immunemechanism sinwhich chemokines and their receptors participate.