Affiliation:
1. Department of Chemistry, Karpagam Academy of Higher Education, Salem-Kochi Highway, Eachanari, Coimbatore, 641 021, India
Abstract
Research background. Obesity increases mortality and morbidity due to its impact on
type 2 diabetes, cardiovascular and gastrointestinal diseases, arthritis and certain cancers.
The epidemic of excessive mass and obesity require constant research to improve therapies
without undesirable side effects. Therefore, exploring the anti-obesity phytochemicals
from food sources is essential. Most pharmacological studies of the anti-obesity potential
of Capsicum annuum have been directed towards capsaicin and very few towards
capsanthin. However, these studies utilized uncoated capsaicin and capsanthin. This study
aims to compare the anti-obesity effects of enteric-coated capsaicin and capsanthin in a
high-fat diet-induced obesity in animal model.
Experimental approach. In this study, we investigated the anti-obesity properties of
capsanthin-enriched pellets and capsaicin pellets derived from red chili fruit (Capsicum
annuum) on high-fat diet (HFD)-induced obesity in C57BL/6J mice. First, the animals received
HFD to induce their obesity. Animals were supplemented orally with pellets. The
food intake, body mass, obesity and clinical biomarkers were assessed.
Results and conclusions. The mice fed with HFD gained body mass and white adipose
tissue mass compared to the mice that consumed a normal diet. The oral administration
of capsanthin-enriched pellets and capsaicin pellets significantly reduced the body mass
gain. These pellets have a statistically significant (p<0.05) impact on obesity biomarkers
by increasing adiponectin and decreasing leptin, free fatty acid and insulin concentrations
relative to HFD control. There was no change in the liver mass in all groups, but there was
a significant decrease in white adipose tissue amounts. Inguinal adipose tissue amount
was reduced by 37.0 % and that of epididymal adipose tissue by 43.64 % after treatment
with capsanthin-enriched pellets. These results suggest that capsanthin-enriched pellets
and capsaicin pellets may be useful in combating metabolic diseases, including obesity,
without adverse effects.
Novelty and scientific contribution. We increased the content of capsanthin for more
than 50 % in capsanthin-enriched extract and extended the room temperature stability
for more than one year by converting the crystals into capsanthin-enriched pellets. This
study breaks new ground by examining the potential of capsanthin >50 % in the management
of obesity for the first time.
Publisher
Faculty of Food Technology and Biotechnology - University of Zagreb
Subject
Industrial and Manufacturing Engineering,General Chemical Engineering,Food Science,Biotechnology
Cited by
3 articles.
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