Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis

Author:

Toyama Shiho1,Takatani Ayuko1,Koga Tomohiro12,Eguchi Mizuna1,Okamoto Momoko1,Tsuji Sosuke1,Endo Yushiro1,Shimizu Toshimasa13,Sumiyoshi Remi1,Igawa Takashi1,Kawashiri Shin-ya14,Iwamoto Naoki1,Ichinose Kunihiro1,Tamai Mami1,Nakamura Hideki1,Origuchi Tomoki1,Furuyama Masako5,Tabuchi Maiko6,Kobayashi Shinichiro7,Kanetaka Kengo7,Hashisako Mikiko8,Abe Kuniko8,Niino Daisuke8,Sato Shinya9,Miyazaki Yasushi10,Kawakami Atsushi1

Affiliation:

1. Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan

2. Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

3. Clinical Research Center, Nagasaki University Hospital, Japan

4. Department of Community Medicine, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan

5. Department of Rheumatology, Nagasaki Kita Hospital, Japan

6. Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

7. Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan

8. Department of Pathology, Nagasaki University Hospital, Japan

9. Department of Hematology, Nagasaki University Hospital, Japan

10. Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference20 articles.

1. 1. Tokuhira M, Watanabe R, Nemoto T, et al. Clinicopathological analyses in patients with other iatrogenic immunodeficiency-associated lymphoproliferative diseases and rheumatoid arthritis. Leuk Lymphoma 53: 616-623, 2012.

2. 2. Rizzi R, Curci P, Delia M, et al. Spontaneous remission of "methotrexate-associated lymphoproliferative disorders" after discontinuation of immunosuppressive treatment for autoimmune disease. Review of the literature. Med Oncol 26: 1-9, 2009.

3. 3. Mariette X, Cazals-Hatem D, Warszawki J, et al. Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France. Blood 99: 3909-3915, 2002.

4. 4. Hoshida Y, Xu JX, Fujita S, et al. Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication. J Rheumatol 34: 322-331, 2007.

5. 5. Ichikawa A, Arakawa F, Kiyasu J, et al. Methotrexate/iatrogenic lymphoproliferative disorders in rheumatoid arthritis: histology, Epstein-Barr virus, and clonality are important predictors of disease progression and regression. Eur J Haematol 91: 20-28, 2013.

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1. Methotrexate/prednisolone/tacrolimus;Reactions Weekly;2020-03

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