The Efficacy of a Genetic Analysis of the BMPR2 Gene in a Patient with Severe Pulmonary Arterial Hypertension and an Atrial Septal Defect Treated with Bilateral Lung Transplantation

Author:

Tatebe Shunsuke1,Sugimura Koichiro1,Aoki Tatsuo1,Yamamoto Saori1,Yaoita Nobuhiro1,Suzuki Hideaki1,Sato Haruka1,Kozu Katsuya1,Konno Ryo1,Satoh Kimio1,Fukuda Koji1,Adachi Osamu2,Saito Ryoko3,Nakanishi Norifumi4,Morisaki Hiroko56,Oyama Kotaro7,Saiki Yoshikatsu2,Okada Yoshinori8,Shimokawa Hiroaki1

Affiliation:

1. Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan

2. Department of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Japan

3. Department of Pathology, Tohoku University School of Medicine, Japan

4. Division of Pulmonary Circulation, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Japan

5. Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center Research Institute, Japan

6. Department of Medical Genetics, Sakakibara Heart Institute, Japan

7. Department of Pediatrics, Iwate Medical University, Japan

8. Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference13 articles.

1. 1. Therrien J, Rambihar S, Newman B, et al. Eisenmenger syndrome and atrial septal defect: nature or nurture? Can J Cardiol 22: 1133-1136, 2006.

2. 2. Soubrier F, Chung WK, Machado R, et al. Genetics and genomics of pulmonary arterial hypertension. J Am Coll Cardiol 62: D13-D21, 2013.

3. 3. Diller GP, Gatzoulis MA. Pulmonary vascular disease in adults with congenital heart disease. Circulation 115: 1039-1050, 2007.

4. 4. D'Alto M, Mahadevan VS. Pulmonary arterial hypertension associated with congenital heart disease. Eur Respir Rev 21: 328-337, 2012.

5. 5. Rabinovitch M. Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 122: 4306-4313, 2012.

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Preventing disease progression in Eisenmenger syndrome;Expert Review of Cardiovascular Therapy;2021-05-06

2. Successful outcomes for atrial septal defect associated with pulmonary arterial hypertension using a “treat-repair-treat” strategy;International Journal of Cardiology Congenital Heart Disease;2021-02

3. Mortality in adult patients with Eisenmenger Syndrome: 5-Years perspective;International Journal of Cardiology Congenital Heart Disease;2021-02

4. New pathogenic variant of BMPR2 in pulmonary arterial hypertension;Cardiology in the Young;2019-04

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