Non-insulin-dependent Diabetes Mellitus Induced by Immune Checkpoint Inhibitor Therapy in an Insulinoma-associated Antigen-2 Autoantibody-positive Patient with Advanced Gastric Cancer

Author:

Ohara Nobumasa1,Kobayashi Michi12,Ikeda Yohei3,Hoshi Takahiro4,Morita Shinichi4,Kanefuji Tsutomu4,Yagi Kazuyoshi4,Suda Takeshi4,Takada Toshinori5,Hasegawa Go6,Sato Yo7,Hirano Kenichiro7,Kosugi Shin-ichi7

Affiliation:

1. Department of Endocrinology and Metabolism, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan

2. Department of Diabetes, Endocrinology and Metabolism, Center Hospital of the National Center for Global Health and Medicine, Japan

3. Department of Radiology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan

4. Department of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan

5. Department of Respiratory Medicine, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan

6. Department of Pathology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan

7. Department of Digestive and General Surgery, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference25 articles.

1. 1. Pennock GK, Chow LQ. The evolving role of immune checkpoint inhibitors in cancer treatment. Oncologist 20: 812-822, 2015.

2. 2. Michot JM, Bigenwald C, Champiat S, et al. Immune-related adverse events with immune checkpoint blockade: a comprehensive review. Eur J Cancer 54: 139-148, 2016.

3. 3. Barroso-Sousa R, Barry WT, Garrido-Castro AC, et al. Incidence of endocrine dysfunction following the use of different immune checkpoint inhibitor regimens: a systematic review and meta-analysis. JAMA Oncol 4: 173-182, 2018.

4. 4. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 37 (Suppl 1): S81-S90, 2014.

5. 5. Winter WE, Schatz DA. Autoimmune markers in diabetes. Clin Chem 57: 168-175, 2011.

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