Efficacy of Combined Thrombomodulin and Antithrombin in Anticoagulant Therapy for Acute Cholangitis-induced Disseminated Intravascular Coagulation

Author:

Morita Nozomi1,Nakahara Kazunari2,Morita Ryo2,Suetani Keigo1,Michikawa Yosuke2,Sato Junya2,Tsuji Kensuke2,Ikeda Hiroki2,Matsunaga Kotaro2,Watanabe Tsunamasa2,Matsumoto Nobuyuki2,Okuse Chiaki1,Suzuki Michihiro1,Itoh Fumio2

Affiliation:

1. Department of Gastroenterology and Hepatology, Kawasaki Municipal Tama Hospital, Japan

2. Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference19 articles.

1. 1. Saito H, Maruyama I, Shimazaki S, et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a pase III, randomized, double-blind clinical traial. J Thromb Haemost 5: 31-41, 2007.

2. 2. Aikawa N, Shimazaki S, Yamamoto Y, et al. Thrombomodulin alfa in the treatment of infectious patients complicated by disseminated intravascular coaglation: subanalysis from the phase 3 trial. Shock 35: 349-354, 2011.

3. 3. Vincent JL, Ramesh MK, Ernest D, et al. A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med 41: 2069-2079, 2013.

4. 4. Yamakawa K, Aihara M, Ogura H, Yuhara H, Hamasaki T, Shimazu T. Recombinant human soluble thrombomodulin in severe sepsis: a systematic review and meta-analysis. J Thromb Haemost 13: 508-519, 2015.

5. 5. Kienast J, Juers M, Wiedermann CJ, et al. Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation. J Thromb Haemost 4: 90-97, 2006.

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