The Efficacy of Reduced-dose Dasatinib as a Subsequent Therapy in Patients with Chronic Myeloid Leukemia in the Chronic Phase: The LD-CML Study of the Kanto CML Study Group

Author:

Iriyama Noriyoshi1,Ohashi Kazuteru2,Hashino Satoshi3,Kimura Shinya4,Nakaseko Chiaki5,Takano Hina6,Hino Masayuki7,Uchiyama Michihiro8,Morita Satoshi9,Sakamoto Junichi10,Sakamaki Hisashi2,Inokuchi Koiti11

Affiliation:

1. Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan

2. Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Japan

3. Health Care Center, Hokkaido University, Japan

4. Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan

5. Department of Hematology, Chiba University Hospital, Japan

6. Department of Hematology, Musashino Red Cross Hospital, Japan

7. Department of Hematology, Osaka City University Hospital, Japan

8. Department of Hematology, Suwa Red Cross Hospital, Japan

9. Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Japan

10. Tokai Central Hospital, Japan

11. Department of Hematology, Nippon Medical School, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference28 articles.

1. 1. Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 355: 2408-2417, 2006.

2. 2. Tauchi T, Kizaki M, Okamoto S, et al. Seven-year follow-up of patients receiving imatinib for the treatment of newly diagnosed chronic myelogenous leukemia by the TARGET system. Leuk Res 35: 585-590, 2011.

3. 3. Ohnishi K, Nakaseko C, Takeuchi J, et al. Long-term outcome following imatinib therapy for chronic myelogenous leukemia, with assessment of dosage and blood levels: the JALSG CML202 study. Cancer Sci 103: 1071-1078, 2012.

4. 4. O'Hare T, Walters DK, Stoffregen EP, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 65: 4500-4505, 2005.

5. 5. Mahon FX, Hayette S, Lagarde V, et al. Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression. Cancer Res 68: 9809-9816, 2008.

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