Successful Treatment of Nivolumab-related Cholangitis with Prednisolone: A Case Report and Review of the Literature

Author:

Sawada Koji1,Shonaka Tatsuya2,Nishikawa Yuji3,Hasegawa Kimiharu2,Hayashi Hidemi1,Hasebe Takumu1,Nakajima Shunsuke1,Ikuta Katsuya1,Fujiya Mikihiro1,Furukawa Hiroyuki2,Okumura Toshikatsu1

Affiliation:

1. Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan

2. Division of Gastroenterological and General Surgery, Department of Surgery, Asahikawa Medical University, Japan

3. Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference27 articles.

1. 1. Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 28: 3167-3175, 2010.

2. 2. Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366: 2443-2454, 2012.

3. 3. Topalian SL, Sznol M, McDermott DF, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 32: 1020-1030, 2014.

4. 4. Rizvi NA, Mazières J, Planchard D, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol 16: 257-265, 2015.

5. 5. Cella D, Grünwald V, Nathan P, et al. Quality of life in patients with advanced renal cell carcinoma given nivolumab versus everolimus in CheckMate 025: a randomised, open-label, phase 3 trial. Lancet Oncol 17: 994-1003, 2016.

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