Efficacy and Safety of Chemotherapy Following Anti-PD-1 Antibody Therapy for Gastric Cancer: A Case of Sclerosing Cholangitis

Author:

Kono Masashi1,Sakurai Toshiharu1,Okamoto Kazuki1,Masaki Shou1,Nagai Tomoyuki1,Komeda Yoriaki1,Kamata Ken1,Minaga Kosuke1,Yamao Kentarou1,Takenaka Mamoru1,Watanabe Tomohiro1,Nishida Naoshi1,Kudo Masatoshi1

Affiliation:

1. Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference23 articles.

1. 1. Kang YK, Boku N, Satoh T, et al. Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 390: 2461-2471, 2017.

2. 2. Weber J. Review: anti-CTLA-4 antibody ipilimumab: case studies of clinical response and immune-related adverse events. Oncologist 12: 864-872, 2007.

3. 3. Kumar V, Chaudhary N, Garg M, et al. Current diagnosis and management of immune related adverse events (irAEs) induced by immune checkpoint inhibitor therapy. Front Pharmacol 8: 49, 2017.

4. 4. Abdalian R, Heathcote EJ. Sclerosing cholangitis: a focus on secondary causes. Hepatology 44: 1063-1074, 2006.

5. 5. Kulaksiz H, Heuberger D, Engler S. et al. Poor outcome in progressive sclerosing cholangitis after septic shock. Endoscopy 40: 214-218, 2008.

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