Eculizumab for Severe Thrombotic Microangiopathy Secondary to Surgical Invasive Stress and Bleeding

Author:

Fujita Yoko1,Terashita Maho1,Yazawa Masahiko1,Yamasaki Yukitaka2,Imamura Tomonori3,Kibayashi Junichiro4,Sawai Toshihiro5,Hidaka Yoshihiko67,Ohtani Katsuki78,Inoue Norimitsu67,Shibagaki Yugo1

Affiliation:

1. Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan

2. Department of Infectious Disease, St. Marianna University School of Medicine, Japan

3. Department of Emergency and Critical Care Medicine, Tokyo Metropolitan Police Hospital, Japan

4. Department of Obstetrics and Gynecology, Yokohama General Hospital, Japan

5. Department of Pediatrics, Shiga University of Medical Science, Japan

6. Department of Molecular Genetics, Wakayama Medical University, Japan

7. The Japanese Association for Complement Research, Japan

8. Department of Food and Health Sciences, Rakuno Gakuen University, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference18 articles.

1. 1. Noris M, Remuzzi G. Atypical hemolytic-uremic syndrome. N Engl J Med 361: 1676-1687, 2009.

2. 2. George JN, Nester CM. Syndromes of thrombotic microangiopathy. N Engl J Med 371: 654-666, 2014.

3. 3. Noris M, Caprioli J, Bresin E, et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol 5: 1844-1859, 2010.

4. 4. Asif A, Nayer A, Haas CS. Atypical hemolytic uremic syndrome in the setting of complement-amplifying conditions: case reports and a review of the evidence for treatment with eculizumab. J Nephrol 30: 347-362, 2017.

5. 5. Riedl M, Fakhouri F, Le Quintrec M, et al. Spectrum of complement-mediated thrombotic microangiopathies: pathogenetic insights identifying novel treatment approaches. Semin Thromb Hemost 40: 444-464, 2014.

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