Sudden Onset Agranulocytosis and Hepatotoxicity after Taking Methimazole

Author:

Yang Jing12,Zhong Jing3,Zhou Ling-Zhi3,Hong Tao1,Xiao Xin-Hua1,Wen Ge-Bo13

Affiliation:

1. Department of Metabolism & Endocrinology of the First Affiliated Hospital, University of South China, China

2. Department of Pathophysiology, University of South China, China

3. Clinical Medical Research Institute of the First Affiliated Hospital, University of South China, China

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference25 articles.

1. 1. He CT, Hsieh AT, Pei D, et al. Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves' hyperthyroidism. Clin Endocrinol (Oxf) 60: 676-681, 2004.

2. 2. Emiliano AB, Governale L, Parks M, Cooper DS. Shifts in propylthiouracil and methimazole prescribing practices: antithyroid drug use in the United States from 1991 to 2008. J Clin Endocrinol Metab 95: 2227-2233, 2010.

3. 3. Cooper DS. Antithyroid drugs. N Engl J Med 352: 905-917, 2005.

4. 4. Tajiri J, Noguchi S. Antithyroid drug-induced agranulocytosis: special reference to normal white blood cell count agranulocytosis. Thyroid 14: 459-462, 2004.

5. 5. Woeber KA. Methimazole-induced hepatotoxicity. Endocr Pract 8: 222-224, 2002.

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