Effects of Olmesartan, an Angiotensin II Receptor Blocker, on Peripheral Insulin Sensitivity in Japanese Subjects with Type 2 Diabetes and Hypertension

Author:

Shimoda Seiya1,Goto Rieko1,Furukawa Noboru1,Tsuruzoe Kaku1,Kawashima Junji1,Iwashita Shinsuke1,Maeda Takako1,Ichimori Shinji2,Ichinose Kenshi1,Nishida Kenro3,Araki Eiichi1

Affiliation:

1. Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan

2. Ueki Hospital, Japan

3. Minamata City Hospital and Medical Center, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference33 articles.

1. 1. Hansson L, Lindholm LH, Niskanen L, et al. Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial. Lancet 353: 611-616, 1999.

2. 2. McMurray JJ, Holman RR, Haffner SM, et al; Navigator Study Group. Effect of valsartan on the incidence of diabetes and cardiovascular events. N Engl J Med 362: 1477-1490, 2010.

3. 3. Uehara M, Kishikawa H, Isami S, et al. Effect on insulin sensitivity of angiotensin converting enzyme inhibitors with or without a sulphydryl group: bradykinin may improve insulin resistance in dogs and humans. Diabetologia 37: 300-307, 1994.

4. 4. Isami S, Kishikawa H, Araki E, et al. Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway. Diabetologia 39: 412-420, 1996.

5. 5. Motoshima H, Araki E, Nishiyama T, et al. Bradykinin enhances insulin receptor tyrosine kinase in 32D cells reconstituted with bradykinin and insulin signaling pathways. Diabetes Res Clin Pract 48: 155-170, 2000.

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